Effect of the Oral Administration of Vitamin B12 to Patients under Distal and Total Gastrectomy.

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  • 胃切除術後および胃全摘術後患者に対するビタミンＢ１２の経口投与の有効性

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Objectives: At high dosage, orally administered vitamin B12 is absorded by a gradient of concentration, not by an intrinsic factor. We studied the effect of oral administration of Mecobalamin (Methicobal) to patients undergoing distal and total gastrectomy. Methods: Eleven patients undergoing distal gastrectomy B-1 and 8 total gastrectomy R-Y were orally administered 1.5 mg/day of Mecobalamin, devided into 3 times/day, for 4 weeks. Blood levels of vitamin B12 were measured. Results: In distal gastrectomy, blood levels of vitamin B12, preceding and after 2 and 4 weeks administration of Mecobalamin, were 412+/-33, 581+/-62, and 701+/-94 pg/ml. In total gastrectomy, they were 312/-40, 440+/-34, and 469+/-30 pg/ml. Oral Mecobalamin administration increased vitamin B12 blood levels in patients undergoing both types of surgery. The correlation between the vitamin B12 blood levels before administration and increasing vitamin B12 after 4 weeks of administration was a significant positive correlation in distal gastrectomy but tended to be negative in total gastrectomy. Conclusion: Oral Mecobalamin administration at the usual dosage effectively provided patients undergoing distal and total gastrectomy with vitamin B12 and easily controlled at the clinic.

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