A Long Surviving Case of Coexistent Endocrine Cell Carcinoma and Well Differentiated Adenocarcinoma in Tubulovillous Adenoma of the Rectum with Lymph Node Involvement
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- Suto Takayuki
- Department of Surgery, Morioka Municipal Hospital
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- Fujita Tomohiro
- Department of Surgery, Morioka Municipal Hospital
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- Mitomo Shingo
- Department of Surgery, Morioka Municipal Hospital
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- Umemura Akira
- Department of Surgery, Morioka Municipal Hospital
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- Ishida Kaoru
- Department of Surgery, Morioka Municipal Hospital
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- Uesugi Noriyuki
- Department of Diagnostic Pathology, School of Medicine, Iwate Medical University
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- Sugai Tamotsu
- Department of Diagnostic Pathology, School of Medicine, Iwate Medical University
Bibliographic Information
- Other Title
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- 腺管絨毛腺腫,高分化腺癌,内分泌細胞癌が共存した直腸内分泌細胞癌長期生存の1例
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Abstract
Endocrine cell carcinoma (ECC) of the rectum is a relatively rare neoplasm with a poor prognosis. The mechanisms of its development and progression remain unclear, and there is no established remedy. We reported a long surviving case of early ECC of the rectum with lymph node involvement. A 57-year-old man with melena was found to have rectal cancer by endoscopy. The tumor was biopsied and diagnosed immunohistochemically as ECC. He underwent low anterior resection with lymph node dissection on October, 2003. Histopathologically, the tumor was composed of fascicular proliferation cells invading the submucosal layer and had lymph node metastasis. Moreover, the tumor cells were immunohistochemically positive for both NCAM and synaptophysin, confirming the diagnosis of ECC. Well differentiated adenocarcinoma (WDA) and tubulovillous adenoma (TVA) coexisted with ECC in the tumor. p53 staining was positive in TVA, WDA and ECC. The MIB-1 index of ECC was higher than those of TVA and WDA. He was discharged on postoperative day 24. He underwent adjuvant chemotherapy with UFT/LV and 5-DFUR. He is alive without recurrence, 8 years and 7 months since surgery. This case suggests that ECC has a high potential of lymph node metastasis and that colectomy with lymphadenectomy is essential to long-term survival even in early cancer. The morphological appearances in this case provide some information on the pathogenesis of ECC.
Journal
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- The Japanese Journal of Gastroenterological Surgery
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The Japanese Journal of Gastroenterological Surgery 46 (2), 143-150, 2013
The Japanese Society of Gastroenterological Surgery
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Details 詳細情報について
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- CRID
- 1390001204916955904
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- NII Article ID
- 130004560921
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- ISSN
- 13489372
- 03869768
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed