Effectiveness of Neoadjuvant Chemotherapy Against Neuroendocrine Carcinoma of the Colon with Duodenal Invasion; Report of a Case
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- Tsutani Yasuhiro
- Department of Surgery, Hiroshima City Hospital
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- Aoki Hideki
- Department of Surgery, Hiroshima City Hospital
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- Harano Masao
- Department of Surgery, Hiroshima City Hospital
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- Sasaki Hiroshi
- Department of Surgery, Hiroshima City Hospital
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- Onoda Tadashi
- Department of Surgery, Hiroshima City Hospital
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- Shiozaki Shigehiro
- Department of Surgery, Hiroshima City Hospital
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- Ohno Satoshi
- Department of Surgery, Hiroshima City Hospital
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- Ninomiya Motoki
- Department of Surgery, Hiroshima City Hospital
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- Takakura Norihisa
- Department of Surgery, Hiroshima City Hospital
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- Seguchi Tomoko
- The Second Department of Pathology, Miyazaki Medical College
Bibliographic Information
- Other Title
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- 術前化学療法が著効し切除しえた十二指腸浸潤大腸内分泌細胞癌の1例
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Abstract
We report a case of neuroendocrine carcinoma of the colon that responded to neoadjuvant chemotherapy. A 38-year-old man admitted for acute myocardial infarction with anemia was found in detailed examination to have neuroendocrine carcinoma of the transverse colon with duodenal invasion. CT showed rapid growth of right upper abdominal tumor resulting in ileus. After temporizing ileostomy, a combination of cisplatin (CDDP) and CPT-11 was given as neoadjuvant chemotherapy. Post chemotherapy CT showed tumor disappearance and radical right hemicolectomy, partial duodenectomy, and cholecystectomy were done. Histopathological examination of surgical specimens showed that only a few carcinoma cells remained in the mucous membrane of the colon, which was histologically Grade 2. After combined CDDP and CPT-11 adjuvant chemotherapy, he was discharged. To date, 14 months after surgery, there is no evidence of recurrence. Neuroendocrine carcinoma of the colon has very poor prognosis and radical treatment cannot be achieved by surgical therapy alone. Combined therapy including neoadjuvant chemotherapy may be effective in fighting this disease.
Journal
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- The Japanese Journal of Gastroenterological Surgery
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The Japanese Journal of Gastroenterological Surgery 37 (8), 1485-1490, 2004
The Japanese Society of Gastroenterological Surgery
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Details 詳細情報について
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- CRID
- 1390001204919889152
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- NII Article ID
- 130004344144
- 10014054507
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- NII Book ID
- AN00192066
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- ISSN
- 13489372
- 03869768
- http://id.crossref.org/issn/03869768
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed