Ideal lifestyles against colorectal tumorigenesis: with explanation for the impact of exercise or obesity on colorectal tumor development

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  • Mutoh Michihiro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center
  • Tamura Shuya
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center
  • Hamoya Takahiro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center
  • Fujii Gen
    Central Radioisotope Division, National Cancer Center Research Institute

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  • 大腸がんの予防に向けた生活習慣 〜運動と肥満からみたメカニズム論を加えて〜
  • ダイチョウ ガン ノ ヨボウ ニ ムケタ セイカツ シュウカン : ウンドウ ト ヒマン カラ ミタ メカニズムロン オ クワエテ

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<p>Obesity-associated cancers, including colorectal cancer, are increasing in Japan with Westernized lifestyles as exemplified by reduced physical activity and increased high-fat diet. An excessive accumulation of visceral adipose tissue causes insulin resistance, oxidative stress and adipocytokine imbalance, and these factors are suggested to be involved in colorectal tumorigenesis. In this review article, we focus on the relationships between each of the individual associated conditions, especially obesity and exercise, and colorectal tumor development with targeting molecules revealed by in vivo and in vitro studies. Furthermore, the potential for colorectal cancer prevention by targeting these molecules is discussed.</p>

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