Essential Roles of Carbohydrate Signals in Development, Immune Response and Tissue Functions, as Revealed by Gene Targeting.
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- Muramatsu Takashi
- Department of Biochemistry, Nagoya University School of Medicine
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Abstract
Knockout mice lacking glycosyltransferases or sulfotransferases provide unequivocal evidence that the carbohydrate moieties of glycoproteins, glycolipids, and proteoglycans play essential roles in various biological phenomena such as development, the immune response, and tissue functions. Examples of abnormalities of null mutants include arrest of embryogenesis due to deletion of N-acetylglucosaminyltransferase I or glucosylceramide synthase, failure of kidney formation in heparan sulfate 2-O-sulfotransferase deficiency, suppressed antibody production in α-2, 6-sialyltransferase deficiency, male sterility in GM2/GD2 synthase deficiency, and abnormalities in the function and stability of myelin in galactosylceramide deficiency.
Journal
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- The Journal of Biochemistry
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The Journal of Biochemistry 127 (2), 171-176, 2000
The Japanese Biochemical Society
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Details 詳細情報について
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- CRID
- 1390001204931236480
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- NII Article ID
- 130003417959
- 10005440880
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- NII Book ID
- AA00694073
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- COI
- 1:CAS:528:DC%2BD3cXit1Ggsbc%3D
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- ISSN
- 17562651
- 0021924X
- http://id.crossref.org/issn/0021924X
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- NDL BIB ID
- 5278293
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- PubMed
- 10731680
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed