Real Time Observation of Binding of Herpes Simplex Virus Type 1 (HSV-1) to Vero Cells and Neutralization of HSV-1 by Sulfonated Human Immunoglobulin.

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  • Real Time Observation of Binding of Her

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Abstract

A real time biomolecular interaction assay system involving an optical sensor was applied to the quantitative analysis of the binding of herpes simplex virus type 1 (HSV-1) to Vero cells, and the neutralization antibody titer against this virus with a commercially available sulfonated human immunoglobulin preparation. The virus titers in a viral solution and the neutralizing antibody titer in the human immunoglobulin preparation could be success-fully estimated in a short time with this system without any difficult cytopathic effect analysis of cultured cells.

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