Myositis ossificans progressiva, a case report and clinical observation of diphosphonate therapy.
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- Ojima Hiroshi
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
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- Ijichi Masateru
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
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- Ito Kenzo
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
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- Tanaka Hiroaki
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
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- Mishima Shinichi
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
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- Yoshida Katsuyuki
- Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health
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- Saeki Chieko
- Department of Rehabilitation Medicine, School of Medicine, University of Occupational and Environmental Health
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- Kurokawa Takahide
- Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo
Bibliographic Information
- Other Title
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- 進行性骨化性筋炎の1例
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Abstract
Myositis ossificans progressive is a rare children's desease, characterized by slowly progressive and multiple ectopic ossification of connective tissues. The cause is unknown and there is no recognized treatment.<br>Recently we have treated a case of myositis ossificans progressiva. A 33-year-old male visited our hospital complaining of difficulty in walking and right side coxalgia. Ectopic ossifications developed from the age of about 14 years, and restriction of motion of spine and joints progressed year by year.<br>There were malformations of great toes which had been noted at birth. The spine was ankylosing and ROM of joints of extremities was severely restricted. Plasma alkaline phosphatase was higher, but plasma calcium and phosphorus were normal. X-rays and bone scintigrams showed multiple ectopic ossifications.<br>We treated this case by 20mg/kg/day of etidronate disodium (ethane-1-hydroxy-1. 1-diphosphonate, “EHDP”) for 3 months along with physical therapy. These treatments gave him a remission of right side coxalgia and widened the range of motion in some joints.<br>We concluded that diphosphonate therapy was effective to some extent in this case.
Journal
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- Orthopedics & Traumatology
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Orthopedics & Traumatology 35 (2), 678-683, 1986
West-Japanese Society of Orthopedics & Traumatology
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Details 詳細情報について
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- CRID
- 1390001204937005568
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- NII Article ID
- 130001635095
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- ISSN
- 13494333
- 00371033
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed