ビスフォスフォネート製剤経口投与が有効であった骨形成不全症の１例

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  • Oral Alendronate Treatment in Osteogenesis Imperfecta: A case report

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Recently, it was reported that cyclic venous administration of bisphosphonate decreased the fracture rate, increased bone mineral density, and improved height gain in osteogenesis imperfecta (OI). We treated an 11-year-old girl with OI type I and vertebral deformities for 2 years with intermittent oral administration of alendronate (15mg/ week). The treatment resulted in markedly increased bone mineral density, decreased back pain, and an amelioration of the vertebral shape. No side effects were encountered. It was suggested that oral administration of alendronate might be a useful treatment for patients with OI and vertebral fractures.

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