Influence of Gd-DTPA2- Contrast Agent on Cartilage T2 Mapping

DOI 13 References
  • Nishioka Hiroaki
    Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  • Hirose Jun
    Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  • Nakamura Eiichi
    Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  • Oniki Yasunari
    Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  • Tanaka Azusa
    Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  • Masuda Tetsuro
    Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  • Mizuta Hiroshi
    Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan

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Other Title
  • ガドリウム造影剤のＴ２マッピングに及ぼす影響

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Purpose: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping are used to characterize articular cartilage. As the contrast agent Gd-DTPA2- may affect the inherent T2 of cartilage, T2 mapping and dGEMRIC are typically conducted in two separate MRI sessions. The aim of this study was to determine whether double-dose (0.2 mmol/kg) Gd-DTPA2- contrast agent has an impact on T2 mapping in clinical studies. Materials and Methods: Five knee joints of five patients with ACL tear were studied using 3T MRI before Gd-DTPA2- administration and 120 minutes after for T2 mapping. We compared the T2 values of each femoral and tibial condyle and evaluated their relation between the two MRI sessions. Results: The mean T2 values before Gd-DTPA2- administration did not differ from those after Gd-DTPA2- administration in each condyle. There was a significant correlation of the T2 values between the two MRI sessions. Conclusion: This study demonstrated that T2 is only slightly affected by clinical Gd-DTPA2- and that combined dGEMRIC and T2 mapping analyses in the presence of Gd-DTPA2- can be applied in a single MRI session.

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