書誌事項
- タイトル別名
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- The Effect of Propofol on Dopaminergic Neuronal Loss in an MPTP-Induced Murine Model of Parkinson's Disease
- プロポフォール ガ マウスパーキンソンビョウ モデル ニ オケル ドパミン シンケイ ショウガイ ニ オヨボス エイキョウ
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抄録
Microglia is the primary immune effector cell in the central nervous system. It is suggested that the increased cyclooxygenase (COX) activity in microglia is implicated in the pathogenesis of a number of neurodegenerative diseases, such as Parkinson's disease (PD). In this study, we demonstrated that propofol suppressed the lipopolysaccharide-induced prostanoid production by microglia due to the suppression of COX enzyme activity. We also demonstrated that, in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced murine model of PD, propofol effectively suppressed the dopaminergic neuronal damage in the substantia nigra pars compacta. These results indicate that propofol might be an intravenous anesthetic of choice when patients with PD require sedation and/or general anesthesia.<br>
収録刊行物
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- 関西医科大学雑誌
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関西医科大学雑誌 63 (0), 189-192, 2012
関西医科大学医学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204945311104
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- NII論文ID
- 130002573355
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- NII書誌ID
- AN00046712
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- ISSN
- 21853851
- 00228400
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- NDL書誌ID
- 024198716
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可