羊水の生理に関する研究

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タイトル別名
  • Studies on the physiology of amniotic fluid
  • ヨウスイ ノ セイリ ニカンスルケンキュウ ヨウスイチュウ ユウリ アミノサン
  • —Concentration of free amino acids in amniotic fluid—
  • ―羊水中遊離アミノ酸濃度について―

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In order to study on the possibility of antenatal diagnosis of abnormal aminoaciduria utilizing amniotic fluid, aminoacid concentration in amniotic fluid was determined.<br>1) Each amino acid concentration was almost in relatively narrow range in both second trimester group (12 cases) and term group (13 cases).<br>2) Arginine and glycin increased from second trimester to term, and histidine decreased. Concentration of other amino acids was almost constant.<br>3) After injection of highly concentrated amino acid solution into amniotic cavity, changes of the concentration were determined.<br>24 hours later, one half or one third of the concentration immediatly after injection remained in amniotic fluid.<br>4) From these results, antenatal diagnosis of abnormal aminoaciduria was considered to be possible by determination of amino acid in amniotic fluid but repeated examination was considered to be necessary because of dynamic change of these concentration

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