Toxicity of a new series of S-n-propyl O-ethyl O-phenyl phosphorothioates to susceptible and resistant house flies, Musca domestica L.

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  • KUDAMATSU Akio
    Department of Medical Zoology, Tokyo Medical and Dental University:Agricultural Chemicals Research Institute, Nihon Tokushu Noyaku Seizo Co. Ltd.
  • IYATOMI Akihiko
    Agricultural Chemicals Research Institute, Nihon Tokushu Noyaku Seizo Co. Ltd.
  • HAYASHI Akifumi
    Department of Medical Zoology, Tokyo Medical and Dental University
  • KANO Rokuro
    Department of Medical Zoology, Tokyo Medical and Dental University

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Other Title
  • 新規な S-プロピルーチオ燐酸エステルの殺虫剤抵抗性イエバエに対する効力について
  • 新規なS-プロピルーチオ燐酸エステルの殺中剤抵抗性イエバエに対する効力について〔英文〕
  • シンキ ナ S プロピルーチオ リンサン エステル ノ サツチュウザイ テイコ

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A number of S-alkyl O-alkyl O-aryl phosphorothiolothionates and thiolates were examined for their toxicities to mice, and organophosphorus insecticide resistant and susceptible strains of house flies. These new asymmetrical phosphorothiolothionates and thiolates having S-n-propyl showed exceptionally higher activity against both susceptible and resistant house flies than the corresponding analogues having other alkyl moieties. Usually low mammalian toxicity was demonstrated by the O-ethyl S-n-propyl O-substituted phenyl phosphoro-thiolothionates. Considering mammalian toxicity and insecticidal activity, prothiophos and its oxygen analogue are the preferred compounds as novel hygienic insecticides in the series.

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