産じょく期におけるβ‐ｅｎｄｏｒｐｈｉｎの動態と生理的意義

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  • A study on the effects of suckling on the release of .BETA.-endorphin in puerperal lactating women.

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β- endorphin (β-Ep) and prolactin (PRL) levels in the sera of 22 normal puerperal lactating women were measured before and 30 min, 60 min and 120 min after suckling.<BR>β-Ep was extracted using the silicic acid method. In 17 cases, β-Ep was measured using the direct RIA method (Anti-β-Ep serum : SRL Inc.). In 5 cases, the specimens were chromatographed and measured using a β-endorphin [125I] RIA Kit (NEN).<BR>PRL levels were measured using a prolactin RIA Kit (Daiichi).<BR>In the non-chromatographed group, β-Ep concentrations before and at 30 min, 60 min and 120 min after suckling were 18.8± 6.0, 21.7±7.2, 21.3±8.6 and 13.7±4.5pg/ml (mean±SD), respectively. β-Ep concentrations after suckling were slightly higher than that before suckling.<BR>In the chromatographed group, β-Ep concentrations were 85.4±16.6, 92.1±14.2 and 95.3±25.6pg/ml (mean±SD) before, and at 30 min and 60 min after suckling, respectively.<BR>The difference in the β-Ep concentrations determined by the two methods might be related to low sensitivity of the direct RIA method, though its specificity is very high. However, in the both groups, the β-Ep response patterns before and after suckling were similar.<BR>The PRL concentration was 203.7±141.9 before suckling. The level increasd to 360.1±248.7 at 30 min, 251.4±133.4 at 60 min and 260.7±55.9ng/ml (mean±SD) at 120 min after suckling (p<0.05).<BR>These results suggest that suckling stimulates β-Ep and PRL release possibly from the pituitary gland. However, there was no significant correlation between β-Ep and PRL concentrations. [Adv Obster Gynecol 47(2) : 316-324, 1995 (H7.3)]

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詳細情報 詳細情報について

  • CRID
    1390001204946425856
  • NII論文ID
    130004188167
  • DOI
    10.11437/sanpunosinpo1949.47.316
  • ISSN
    13476742
    03708446
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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