Enhanced cytotoxic T cell function and suppression of tumor development by Mst1 deficiency

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  • Mst1欠損による増強された細胞障害性T細胞の機能と腫瘍発達の抑制
  • Mst1 ケッソン ニ ヨル ゾウキョウ サレタ サイボウ ショウガイセイ Tサイボウ ノ キノウ ト シュヨウ ハッタツ ノ ヨクセイ

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<p>Cytotoxic CD8 T lymphocytes are the major cells of the immune response to viral infection and tumor rejection. Differentiated CTLs have a large number of modified lysosomes including perforin and granzyme B.</p><p>Mammalian ste-20 like kinase Mst1 is abundantly expressed on lymphocytes and plays important roles during apoptosis, proliferation, cell polarity, and migration.</p><p>Here, we report the new role of Mst1 for cytotoxic T-cell responses and tumor reduction.</p><p>Mst1–/– cytotoxic T cells also showed enhanced T-bet expression associated with elevated expression levels of IFNγ and granzyme B.</p><p>In addition, Mst1–/– cytotoxic T cells suppressed tumor growth and prolonged overall survival of tumor bearing mice in vivo.</p><p>Thus, Mst1 is a potential therapeutic target for tumor immunotherapy.</p>

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