The effects of irradiation on multidrug resistance in a non-small lung cancer cell line

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  • 放射線照射による非小細胞肺癌株における多剤耐性能への影響
  • ホウシャセン ショウシャ ニ ヨル ヒショウサイボウ ハイガンカブ ニ オケル タザイ タイセイノウ エ ノ エイキョウ

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<p>Multi-drug resistance (MDR) in cancer is known to decrease the therapeutic efficacy of chemotherapy. The effects of irradiation on MDR in cancer cells remain unclear. Tc-99m methoxyisobutylisonitrile (MIBI) exhibits the same ATP-binding ­cassette (ABC) transporter kinetics as the chemotherapeutic compounds doxorubicin and cisplatin. In this study, we investigated the synergistic effects of chemotherapeutics and irradiation in the non-small lung cancer cell line, H1299 exhibiting MDR, on MIBI and doxorubicin ABC transporter kinetics, in vitro and in vivo, respectively. The irradiation has an inhibitory effect on MDR while a cellular proliferation is suppressed. Furthermore it was necessary to consider the most suitable irradiation protocol in chemoradiotherapy because the radiation effect to restrain MDR is reversible change.</p>

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