A new method for the treatment of blood group-incompatible pregnancy.

DOI
  • YAMAMOTO Yoshiaki
    Department of Obstetrics and Gynecology, Shiga University of Medical Science
  • INABA Sakae
    Department of Obstetrics and Gynecology, Shiga University of Medical Science
  • YAMAMOTO Akiko
    Department of Obstetrics and Gynecology, Shiga University of Medical Science
  • TAKAHASHI Yoshiki
    Department of Obstetrics and Gynecology, Shiga University of Medical Science
  • ISHIGURO Tatsuya
    Department of Obstetrics and Gynecology, Shiga University of Medical Science
  • YOSHIDA Yoshinobu
    Department of Obstetrics and Gynecology, Shiga University of Medical Science
  • FUJIYAMA Yoshihide
    Second Department of Internal Medicine, Shiga University of Medical Science
  • MORO Hiroko
    Department of Laboratory Medicine, Shiga University of Medical Science
  • KATAOKA Akira
    Red Cross Blood Center of Shiga

Bibliographic Information

Other Title
  • 血液型（抗Ｄｉｂ）不適合妊娠に対する新しい母体治療の経験　免疫吸着剤（ＩＭ‐Ｐ３５０）による血しょう浄化法の応用

Abstract

Using an immunoadsorbent column (IM-P), we have found an effective treatment of blood group incompatible pregnancy (anti Diego b) with minimum side effects. The patient had a history of blood transfusion given at 12 years of age, and her first child had required exchange transfusion. She had a high titer of IgG anti-Dib before this pregnancy. Because the ΔOD 450 values of the amniotic fluid were elevated to zone 2 A of Liley's graph at 32 weeks of gestation, we performed plasma cleaning with IM-P. After the first treatment, the ΔOD 450 value fell to zone 3 of Liley's graph, and the anti-Dib titer in the maternal blood was kept at low levels by three more plasma cleanings until delivery. A viable mature but anemic newborn was delivered at 38 weeks of gestation and required exchange transfusion.<BR>The immunoadsorbent column (IM-P) is a muliporous polyvinyl alcohol gel, on which surface phenylalanine is immobilized as a ligand. This column has been used for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients. As plasma protein did not decrease after plasma cleaning with this column, neither fresh frozen plasma nor plasma protein fraction was required for this procedure. They are required for plasmapheresis and sometimes cause hepatitis. Plasma IgG and IgA values fell sligtly with this treatment, but no other abnormal values were noted.This immunoadsorbent column may be applicable for the management of other blood type incompatible pregnancies.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390001204946777600
  • NII Article ID
    130004188049
  • DOI
    10.11437/sanpunosinpo1949.42.499
  • ISSN
    13476742
    03708446
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top