Long-term germ stem cells express Bmi1

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  • Komai Yoshihiro
    Department of Stem Cell Pathology, Kansai Medical University Department of Urology and Andrology, Kansai Medical University
  • Tanaka Toshihiro
    Department of Stem Cell Pathology, Kansai Medical University Third Department of Internal Medicine, Kansai Medical University
  • Tokuyama Yoko
    Department of Stem Cell Pathology, Kansai Medical University
  • Yanai Hirotsugu
    Department of Stem Cell Pathology, Kansai Medical University Department of Surgery, Kansai Medical University
  • Ohe Shuichi
    Department of Stem Cell Pathology, Kansai Medical University Department of Dermatology, Kansai Medical University
  • Omachi Taichi
    Department of Stem Cell Pathology, Kansai Medical University Department of Pediatrics, Kansai Medical University
  • Atsumi Naho
    Department of Stem Cell Pathology, Kansai Medical University
  • Yoshida Naoko
    Department of Stem Cell Pathology, Kansai Medical University
  • Kumano Keiki
    Department of Stem Cell Pathology, Kansai Medical University
  • Hisha Hiroko
    Department of Stem Cell Pathology, Kansai Medical University
  • Matsuda Tadashi
    Department of Urology and Andrology, Kansai Medical University
  • Ueno Hiroo
    Department of Stem Cell Pathology, Kansai Medical University

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Other Title
  • 長期生殖幹細胞におけるBmi1の発現
  • チョウキ セイショク カンサイボウ ニ オケル Bmi1 ノ ハツゲン

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Abstract

<p>Recent studies have identified markers for germ stem cells (GSCs) in the testis, such as Nanos2, Ngn3, and c-kit. The differentiation-stage specific expression of these markers indicates a hierarchical relationship between GSC populations and their plasticity. However, the exact nature of most primitive fraction of Asingle GSCs is unclear because direct kinetic assay of Asingle GSCs have not been performed. Here we show that Bmi1 is a specific marker for Asingle GSCs. Bmi1-positive GSCs are a part of GFRα1-positive GSCs, furthermore its expression correlates with the seminiferous stages. Bmi1 expression is followed by proliferative stage of Asingle GSCs. Bmi1-positive GSCs maintain spermatogenesis. They are resistant to irradiation-induced injury, and they regenerate. Thus, the present study first indicates that Bmi1 is a novel marker for Asingle GSCs whose cyclic expression suggests a regulatory role in the seminiferous stages.</p>

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