Prognostic factors of outcome in neonates born at less than 29 weeks of gestation because of threatened premature labor

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  • UJITA Naoya
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine
  • TANIMURA Kenji
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine
  • TAIRAKU Sinya
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine
  • MAESAWA Yoko
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine
  • MORIZANE Mayumi
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine
  • DEGUCHI Masashi
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine
  • MORIOKA Ichiro
    Department of Pediatrics, Kobe University Graduate School of Medicine
  • YAMADA Hideto
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine

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Other Title
  • 切迫早産入院管理の結果, 妊娠29週未満で早産となった児の予後に関連する因子の検討
  • セッパク ソウザン ニュウイン カンリ ノ ケッカ,ニンシン 29シュウ ミマン デ ソウザン ト ナッタ ジ ノ ヨゴ ニ カンレン スル インシ ノ ケントウ

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Objective: We aimed to evaluate prognostic factors of outcome in neonates born at less than 29 weeks of gestation (GW) because of threatened premature labor. Patients and Methods: This was a retrospective study including 43 neonates who were born in our hospital between 2005 and 2014. These neonates were divided into two groups according to the outcome: good (healthy) and poor (handicapped or dead). We examined the following factors: GW at delivery, the presence of rupture of the membranes, maximum maternal leukocyte count 15000/μl and serum CRP level 2.0 mg/dl, highest maternal body temperature 37.5 degrees, maternal steroid administration, male sex, standard deviation of birthweight, and stage of chorioamnionitis grade 2. The prognostic factors for poor outcome were determined by uni- and multivariate logistic regression analyses. Results: Logistic regression analyses showed that GW at delivery was an independent prognostic factor of outcome of neonates (OR, 0.5; 95% CI, 0.3-0.9; p=0.03). Conclusions: This study suggests that the prognosis of neonates who are born at less than 29 GW because of threatened premature labor is associated with earlier GW at delivery. [Adv Obstet Gynecol, 68(2) : 69-74, 2016 (H28.5)]

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