Studies on the mode of inheritance of dieldrin-resistance in larvae of Culex tritaeniorhynchus

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  • Umino Tokuko
    Department of Parasitology, The Institute of Medical Science, The University of Tokyo:Takeda Chemical Industries Ltd.
  • Suzuki Takeshi
    Department of Parasitology, The Institute of Medical Science, The University of Tokyo:Division of Pest Control Japan Environmental Sanitation Center

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Other Title
  • コガタアカイエカ幼虫の dieldrin 抵抗性の遺伝様式について
  • コガタアカイエカ ヨウチュウ ノ dieldrin テイコウセイ ノ イデン ヨウシキ ニ ツイテ

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Abstract

A colony of Culex tritaeniorhynchus highly resistant to dieldrin was collected in Okayama, western Japan, in September 1967. Since it had been known that wild populations of this species of mosquitoes were usully difficult to be colonized in the laboratories but that hybrids were easily established by the crosses between the wild males and the laboratory adapted females, crossing experiments were carried out with the Okayama males and 406 colony females, which were dieldrin susceptible and had been maintained as laboratory colonies for several years. The hybrid colony was successfully established, and apparently homozygous resistant colony (RR) was established by selecting the hybrid colony with dieldrin for 6 generations, the LC-50 being 0.15 ppm, which was approximately 100 times higher than the SS colony. Crossing experiments were carried out between the RR colony and the 406 colony, which was purely susceptible (SS) to dieldrin. The ld-p line (log dosage-probit mortality regression line) of F1 was a straight line located intermediate between two lines, i.e. RR and SS. (See Fig. 3) The results of F2 show distinct evidence of segregation into susceptible, hybrid and resistant individuals in 1 : 2 : 1 ratio, as witnessed by plateaus at the 25% and 75% mortality level in the ld-p line. (See Fig. 4) The results of both backcrosses show distinct evidence of segregation in 1 : 1 ratio, as witnessed by a plateau at the 50% mortality level in the ld-p line. (See Fig. 5) Investigation of the mode of inheritance of dieldrin-resistance in C. trit. larvae has given results entirely consistent with monofactorial inheritance by an autosomal gene of intermediate dominance.

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