Two cases of pregnancy complicated by myotonic dystrophy and facioscapulohumeral muscular dystrophy

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  • WAKIMOTO Yu
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • SAWAI Hideaki
    Department of Obstetrics and Gynecology, Hyogo College of Medicine Department of Clinical Genetics, Hyogo College of Medicine
  • KAMEI Hidetake
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • MORIMOTO Atsushi
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • UKITA Yuji
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • WAKIMOTO Goh
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • TANAKA Hiroyuki
    Department of Obstetrics and Gynecology, Hyogo College of Medicine
  • SHIBAHARA Hiroaki
    Department of Obstetrics and Gynecology, Hyogo College of Medicine

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Other Title
  • 筋強直性ジストロフィー合併妊娠および顔面肩甲上腕型筋ジスロトフィー合併妊娠の2症例
  • キン ゴウチョクセイ ジストロフィー ガッペイ ニンシン オヨビ ガンメン ケン コウ ジョウ ワンガタキン ジスロトフィー ガッペイ ニンシン ノ 2 ショウレイ

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<p>Muscular dystrophy is a hereditary disease that causes progressive weakness, mainly by degeneration and necrosis of the muscle fibers. We experienced the perinatal management of two different types of dystrophy; myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD). The patient with DM presented with polyhydramnios. An emergent Cesarean section was performed at 34 weeks and two days of gestation due to non-reassuring fetal status. The newborn had respiratory and hemodynamic difficulties and died on the 123rd day after birth. The patient with FSHD showed fetal growth restriction and oligohydramnios. Labor onset developed at 39 weeks and one day of gestation, but an emergent Caesarean section was performed due to arrest of labor. Although it has not yet been confirmed whether the newborn carries genes for FSHD, he was discharged from our hospital in a good state. In the perinatal management of these two cases, both needed tocolytic therapy for threatened preterm labor. We chose isoxsuprine hydrochloride for tocolytic therapy to lower the risk of rhabdomyolysis, which is a known side effect of ritodrine hydrochloride. We described the perinatal management of two pregnancies complicated by muscular dystrophy without severe exacerbation of the primary disease.[Adv Obstet Gynecol, 69 (3) : 282-287, 2017 (H29.8)]</p>

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