The efficacy of topical estrogen application on the pealed vaginal wall after vaginectomy in a case of VAIN3 ; a case report

TAKAKURA Masahito, HAMANISHI Junzo, BABA Tsukasa, KOBAYASHI Hironao, YOSHIOKA Yumiko, MATSUMURA Noriomi, KONISHI Ikuo

doi:10.11437/sanpunosinpo.66.114

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腟切除創部にエストラジオールゲル製剤を塗布し,機能的腟を再生し得た1症例
症例報告腟切除創部にエストラジオールゲル製剤を塗布し,機能的腟を再生し得た1症例
ショウレイホウコクチツセツジョソウブニエストラジオールゲルセイザイオトフシ,キノウテキチツオサイセイシエタ 1 ショウレイ

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Abstract

Vaginal intraepithelial neoplasia (VAIN), a pre-neoplastic lesion of the female genital tract, coud not be completely cured after first treatment. After several sessions of laser-evaporation or fragmental excision, many patients undergo total vaginectomy followed by colpocleisis, resulting in loss of vaginal function and dysuria. However, the necessity of maintaining quality of life even after radical surgeries has steadily increased. Here, we report the case of a 47-year-old woman with refractory VAIN3 after hysterectomy for cervical cancer stage Ia1. The patient underwent CO₂ laser evaporation twice within two years after hysterectomy, and finally underwent total vaginectomy followed by sequential application of topical estradiol gel on the surface of the vaginal wall. After three months of treatment, the vaginal surface was covered with new epithelium, forming a neo-vagina, and vaginal function was successfully preserved. This case demonstrates the efficacy of the simple treatment method of topical estradiol application after vaginectomy. [Adv Obstet Gynecol, 66 (2) : 114-118, 2014 (H26.5)]

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ADVANCES IN OBSTETRICS AND GYNECOLOGY

ADVANCES IN OBSTETRICS AND GYNECOLOGY 66 (2), 114-118, 2014

THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN

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