癒着性中耳炎の成因に関する実験的研究

DOI 被引用文献1件
  • 関 哲郎
    東京慈恵会医科大学耳鼻咽喉科学教室
  • 山口 龍二
    神奈川県衛生看護専門学校付属病院耳鼻咽喉科
  • 森山 寛
    東京慈恵会医科大学耳鼻咽喉科学教室

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タイトル別名
  • Experimental Study on the Origin of Adhesive Otitis Media.

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Adhesive otitis media is generally thought to be a sequelae of otitis media with effusion. However, past studies on experimental otitis media in animals found no evidence to support this hypothesis. I created an animal model with long-standing dysfunction of the eustachian tube, but adhesive otitis media was induced in few animals.<BR>Recently O-kubo reported that gas metabolism in the middle ear cavity plays an important role in ventilation of middle ear cavity, so we considered that impaired gas metabolism in the middle ear cavity and eustachian tube dysfunction might be involved in the pathogenesis of adhesive otitis media.<BR>We used Mongolian gerbils. A small opening was made into the bulla. Through the opening, the tympanic orifice of the eustachian tube was electrocauterized in order to block the tube, and the mucous membrane of the middle ear cavity was curetted in order to damage the membrane. Animals were sacrificed 12-16 weeks after the surgical treatment. We used 37 animals. The tympanic membrane was adherent to the promontory wall in four ears. Granulation was formed in the middle ear cavity, and retracted tympanic membrane was adherent to the promontory wall through granulation in seven ears. This study supports the hypothesis that the damage to the mucous membrane of the middle ear cavity as well as dysfunction or occlusion of the eustachian tube plays an important role in the pathogenesis of adhesive otitis media. This model is good for understanding the pathogenesis of adhesive otitis media,

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