自由走行がステロイドミオパシーラットの筋線維に及ぼす影響について

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タイトル別名
  • Effects of Exercise on Muscle Fibers in Steroid Myopathy Rats: A Histochemical Study.
  • ジユウ ソウコウ ガ ステロイドミオパシーラット ノ キンセンイ ニ オヨボス
  • A Histochemical Study

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説明

To clarify the effect of therapeutic exercises in neuromuscular diseases, we investigated influences of endurance training on muscle fibers in experimental steroid myopathy.<br>With the use of 8-week-old male Wistar rats, we made comparisons among 3 groups. Control group (Co), 5 rats, no steroid nor exercise for 8 weeks. Steroid Group (S), 48 rats, has given 1mg/kg triamcinolone acetate every day for the same period without exercise. Steroid and Exercise group (SE) comprised 16 rats, injected the same amount of daily steroid after free-running exercise for 8 weeks.<br>At sacrifice, we obtained soleus (SOL) and extensor digitorum longus (EDL) muscle samples. These samples were stained for myofibrillar ATPase, after preincubation at pH 10.8, 4.6 and 4.3, to identify four major types of muscle fiber. For each fiber type, we measured fiber areas for comparison. A cluster of 200 muscle fibers was selected for measurement in each sample.<br>The results revealed type 2B dominant muscle fiber atrophy in group S and SE. The extent of atrophy, however, was lower in group SE. Besides there was no evidence of muscle fiber damage. Exercise may prevent steroid induced atrophy of muscle fibers.<br>In addition, steroid also transforms from type 1 to type 2 fibers and free running exercise may transform from type 2 to type 1.

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