Effects of Beta-Blocker on Emotional Incontinence in Stroke Patients.

TAKESAKO Ken-ichi, KAWAHIRA Kazumi, HIYOSHI Toshiki, KAWATSU Manabu, KAMITUCHIHASHI Hiroshi, TOGO Shin-ichi, TANAKA Nobuyuki

doi:10.2490/jjrm1963.31.173

Bibliographic Information

Other Title

脳卒中の感情失禁に対するβ‐遮断薬の効果について
ノウソッチュウノカンジョウシッキンニタイスルベータシャダンヤク

Search this article

Description

Several kinds of β-blocker were given orally to 23 patients with emotional incontinence after stroke. By the treatment for more than 2 weeks, the symptom improved markedly in 26.1%, moderately in 26.1% and slightly in 13.0%. Cessation of medication in 6 patients showing the improvement of emotional incontinence resulted in the evident aggravation of the symptoms in 5 patients within a week. There was no difference in the efficacy of β-blockers due to sex, age and the site of brain damage.<br>Propranolol and atenolol which were different in hydrophobicity, i. e. blood brain barrier-permeability and β_{1, 2} receptor selectivity were similarly effective. These results would suggest that the effects of β-blocker on emotional incontinence is attributable to the suppression of central β₁-adrenergic mechanisms related to the generation or expression of emotion, and that blood brain barrier is damaged in stroke patients. Although more detailed studies on doses and indications are required, β-blocker is expected as an effective tool for emotional incontinence after stroke.

Journal

The Japanese Journal of Rehabilitation Medicine

The Japanese Journal of Rehabilitation Medicine 31 (3), 173-177, 1994

The Japanese Association of Rehabilitation Medicine

Keywords

Details 詳細情報について

Export

Report a problem