Three cases of drug-induced eruption due to Solu-Medrol.

DOI
  • Moriwaki Hiroto
    Department of Otorhinolaryngology, The Jikei University School of Medicine
  • Ishii Masanori
    Department of Otorhinolaryngology, Tokyo Kouseinenkin Hospital
  • Yaguchi Yuichiro
    Department of Otorhinolaryngology, Tokyo Kouseinenkin Hospital
  • Hamada Yukio
    Department of Otorhinolaryngology, Tokyo Kouseinenkin Hospital

Bibliographic Information

Other Title
  • 急性末梢神経障害に対して用いたソル・メドロールによる紅斑型薬疹の３例について

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Description

We report 3 cases of extremely rare, delayed, drug-induced eruption caused by Solu-Medrol ® (methylprednisolone sodium succinate) to treat acute peripheral neuropathy. One developed into extremely serious erythroderma requiring systemic management. We studied other corticosteroid preparations possibly causing allergic reactions and considered antigenicity based on chemical structure. We assumed the first case was one in which the prednisolone skeleton acted as an antigen regardless of the methyl and succinate groups.

Journal

  • JIBI INKOKA TEMBO

    JIBI INKOKA TEMBO 44 (2), 120-125, 2001

    Society of Oto-rhino-laryngology Tokyo

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