A 23kD molecule of Plasmodium falciparum binds specific IgG from splenomegalic, parasitemic, but asymptomatic children. A pilot study in a malarious community in Palawan, The Philippines.
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- TONGOL-RIVERA PILARITA
- Department of Parasitology, Gunma University School of Medicine Department of Parasitology, College of Public Health, University of the Philippines Manila
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- KANO SHIGEYUKI
- Department of Parasitology, Gunma University School of Medicine
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- CANETE-MIGUEL EDITHA
- Palawan Provincial Hospital
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- SUZUKI MAMORU
- Department of Parasitology, Gunma University School of Medicine
Bibliographic Information
- Other Title
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- 23kD Molecule of Plasmodium falciparum
- A PILOT STUDY IN A MALARIOUS COMMUNITY IN PALAWAN, THE PHILIPPINES
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Abstract
A pilot sero-epidemiological study was performed in Palawan, The Philippines, in a community within which annual malarial transmission takes place. Sera obtained from splenomegalic and asymptomatic children with current falciparum infection (Group I) were examined using a Western blotting technique to determine the reactivity to electrophoresed antigenic molecules of Plasmodium falciparum (P.f.) . Group I sera consistently exhibited specific reactivity of IgG to a 23kD molecule, to which sera obtained from another group of asymptomatic children with neither parasitemia nor splenomegaly (Group II) exhibited no distinct reactivity. A 58kD molecule was also exhibited by the Group I sera, while several Group II sera reacted with a 52 kD molecule in association with the 47kD which was reported to be indicative of present and/or recent past clinical episode of falciparum infection. Determination of the immunological features of the antigenic molecules of parasites by this type of sero-epidemiological study will provide a new assay system for evaluation of immune status in communities endemic for malaria.
Journal
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- Japanese Journal of Tropical Medicine and Hygiene
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Japanese Journal of Tropical Medicine and Hygiene 25 (1), 1-5, 1997
Japanese Society of Tropical Medicine
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Details 詳細情報について
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- CRID
- 1390001204951786368
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- NII Article ID
- 130003975935
- 10011490759
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- NII Book ID
- AN00196023
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- ISSN
- 21861781
- 21861811
- 03042146
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- NDL BIB ID
- 4174562
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed