EFFICACY OF A SUSTAINED-RELEASE FORMULATION OF AZITHROMYCIN FOR POSTOPERATIVE EXACERBATION OF CHRONIC RHINOSINUSITIS

DOI
  • Asaka Daiya
    Department of Otorhinolaryngology, The Jikei University School of Medicine
  • Yoshikawa Mamoru
    Department of Otorhinolaryngology, The Jikei University School of Medicine
  • Nakayama Tsuguhisa
    Department of Otorhinolaryngology, The Jikei University School of Medicine
  • Okushi Tetsushi
    Department of Otorhinolaryngology, The Jikei University School of Medicine
  • Otori Nobuyoshi
    Department of Otorhinolaryngology, The Jikei University School of Medicine
  • Moriyama Hiroshi
    Department of Otorhinolaryngology, The Jikei University School of Medicine

Bibliographic Information

Other Title
  • 慢性副鼻腔炎術後急性増悪に対するアジスロマイシン単回投与製剤の有用性

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Description

We report the efficacy of a single 2.0g dose of a novel azithromycin microsphere formulation as compared with that of levofloxacin 500mg/day in patients with postoperative exacerbation of chronic rhinosinusitis. Thirty patients who had undergone endoscopic sinus surgery were divided into two groups (azithromycin microspheres group, n=15; oral levofloxacin group, n=15).<br>The primary endpoint was the clinical efficacy on Day 14. The overall clinical efficacy of antibiotic treatment was 83.3% (25/30 subjects); when analyzed by the antibiotic, the efficacy rate was 86.7% (13/15 subjects) in the azithromycin microspheres group and 80% (12/15 subjects) in the levofloxacin group. The bacteriological response (eradication rate) rate on Day 14 was 71.4% (10/14 subjects) in the azithromycin group and 92.3% (12/13 subjects) in the levofloxacin group.<br>These results indicate that the microsphere formulation of azithromycin is effective for the treatment of postoperative exacerbation of chronic rhinosinusitis.

Journal

  • JIBI INKOKA TEMBO

    JIBI INKOKA TEMBO 53 (4), 239-245, 2010

    Society of Oto-rhino-laryngology Tokyo

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