Growth inhibition of Plasmodium falciparum and interleukin-8 production by peripheral blood mononuclear and polymorphonuclear cells in vitro.
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- OHYA JULIETA YURI
- Department of Medical Zoology, Jichi Medical School
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- MATSUOKA HIROYUKI
- Department of Medical Zoology, Jichi Medical School
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- MUKAIDA NAOFUMI
- Cancer Research Institute, Kanazawa University
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- KASAHARA TADASI
- Kyoritsu College of Pharmacy
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- ISHII AKIRA
- Department of Medical Zoology, Jichi Medical School
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Description
Peripheral blood mononuclear and polymorphonuclear cells have been demonstrated to kill and inhibit malaria parasite proliferation in vitro, but most of the reports required activation of the cells by cytokines or presence of immune sera or opsonins. In our study, peripheral blood leukocytes from non-immune donor efficiently inhibited Plasmodium falciparum growth, depending on the effecter/target ratio. Moreover, these cells produced a large amount of interlenkin-8 (IL-8) under stimulation with infected erythrocytes or supernatant of the Plasmodium falciparum culture. IL-8 secretion in the culture supernatant of polymorphonuclear cells was noted from 6-9 hr of stimulation with the parasites, with a substantial increase over 24 hours of culture. Attempt to elucidate whether IL-8 was involved in malaria suppression was done, and the result suggested that IL-8 was not directly involved in the anti-malarial activity of the mononuclear and polymorphonuclear cells. The other mechanism besides IL-8 may work for inhibiting parasite growth in the culture system of malaria parasites associated with leukocytes.
Journal
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- Japanese Journal of Tropical Medicine and Hygiene
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Japanese Journal of Tropical Medicine and Hygiene 30 (4), 351-355, 2002
Japanese Society of Tropical Medicine
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Details 詳細情報について
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- CRID
- 1390001204953400960
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- NII Article ID
- 130003975999
- 10011518458
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- NII Book ID
- AN00196023
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- ISSN
- 21861781
- 21861811
- 03042146
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- NDL BIB ID
- 6452970
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed