Adsorption and permeability of low molecular weight heparin on high flux hemodialysis membranes.

DOI

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Other Title
  • 各種高性能透析膜における低分子ヘパリンの吸着特性および透過性の検討

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Description

The aim of our study was to clarify the effect of high flux dialysis membranes on the adsorption and permeability of low molecular weight heparin (LMWH). The dialyzers investigated were AM-GP (ASAHI), CL-SS (TERUMO), KF-C (KAWASUMI), BK-P (TORAY), PS (KAWASUMI), FLX (NIKKISO) and BLX (NIKKISO). In vitro study using such as CL-SS/KF-C/AM-GP/BK-P/PS/FLX/BLX (QB=100ml/min, QF=10ml/min) revealed that the average values of SC of LMWH were 0.39/0.53/0.56/0.79/0.87/1.03/0.00, respectively. Similary, the adsorption of LMWH was recognized only in BLX. Using BLX/AM-GP/BK-P/KF-C/FLX in clinical study (QB=200ml/min, QF=30ml/min) the reduction rate of LMWH on 15 min filtration were 71.9%/21.4%/19.9%/13.7%/3.3%, respectively, and statisti-cal significant decleases were found in all dialyzers except FLX. LMWH in filtrate was detected in only two types of dialyzers such as BK-P and FLX, respectively, and the mean SC of BK-P and FLX were 0.064 and 0.017.<br>In conclusion, the time and the site of LMWH injection is the critical points to be determined when hemodialysis is conducted using high flux membrane dialyzers. In addition, the dose of LMWH should be increased when BLX is used.

Journal

  • Jinko Zoki

    Jinko Zoki 23 (2), 412-416, 1994

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

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Details 詳細情報について

  • CRID
    1390001204954218624
  • NII Article ID
    130001732446
  • DOI
    10.11392/jsao1972.23.412
  • ISSN
    18836097
    03000818
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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