ＰＥＴ代用血管用血栓バインダーの分子設計と調製

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  • Design and Preparation of Clot Binding Agent for PET Vascular Grafts.

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We prepare amphiphilic clots binders consist of acylated gelatin to improve the functions of PET vascular graft by a novel synthetic method by which we obtained the acylated gelatin under mild reaction conditions. We find that the acylated gelatin is one of a thermoreversible gel forming materials. When the gel is cast on a PET film, it is found that the resultant gel tightly stuck on the PET surface that suggests the acyl groups strongly interact with the PET film by the hydrophobic interaction. Although the existence of the hydrophobic groups, the surface of the acylated gelatin gel is entirely hydrophilic. We also find that the melting temperatures of the acylated gelatin gels are rather higher than that of original gelatin gels that suggests the cross linking regions of the acylated gelatin gel may be stabilized by the hydrophobic interactions between acyl groups. These results indicate that the acylation of gelatin causes the preferable changes to the gelatin gel as a clots binding agent for PET vascular grafts.

収録刊行物

  • 人工臓器

    人工臓器 23 (3), 650-653, 1994

    一般社団法人 日本人工臓器学会

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