Study of the EDA(+) fibronectin recognition structure on heparin.
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- Miyamoto K
- Mie University
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- Ito T
- Mie University
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- Maeda R
- Mie University
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- Tokita M
- Mie University
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- Komai T
- Mie University
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- Miyashita K
- 大塚製薬工場株式会社
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- Sakashita E
- 大塚製薬工場株式会社
Bibliographic Information
- Other Title
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- ヘパリンのEDA(+)フィブロネクチン認識構造に関する研究
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Abstract
Study of the EDA (+) fibronectin recognition structure on heparin. We carried out research into an absorber to remove EDA (+) fibronectin (EDA (+) FN) from the blood by using heparin. The elucidation of the EDA (+) FN recognition structure of the heparin is necessary for the development of the effective material. In this study, the examination of recognition structure for EDA (+) FN was carried out by using desulfate heparin and the heparin oligomer. The association constant (KA) of EDA (+) FN and the heparin decreased gradually (1.0E+8→1.0E+7M-1) with desulfate treatment. There was hardly the change in KA with the decline of the molecular weight. As for the EDA (+) FN recognition structure of the heparin, our results showed that it was a low molecular weight level (less than MW=1.0E+3). We also found that the peculiar arrangement structure was not necessary.
Journal
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- Jinko Zoki
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Jinko Zoki 28 (1), 191-195, 1999
JAPANESE SOCIETY FOR ARTIFICIAL ORGANS
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Details 詳細情報について
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- CRID
- 1390001204955008896
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- NII Article ID
- 10005943550
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- NII Book ID
- AN00120167
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- ISSN
- 18836097
- 03000818
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed