ハプトグロビン投与による弁置換術後慢性溶血の評価
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- 塩井 健介
- he Second Department of Surgery, AichiMedical University
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- 永田 昌久
- he Second Department of Surgery, AichiMedical University
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- 岡崎 信彦
- he Second Department of Surgery, AichiMedical University
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- 間瀬 武則
- he Second Department of Surgery, AichiMedical University
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- 上床 邦彦
- he Second Department of Surgery, AichiMedical University
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- 浅井 忠彦
- he Second Department of Surgery, AichiMedical University
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- 加藤 真司
- he Second Department of Surgery, AichiMedical University
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- 小林 正治
- he Second Department of Surgery, AichiMedical University
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- 土岡 弘通
- he Second Department of Surgery, AichiMedical University
書誌事項
- タイトル別名
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- EVALUATION OF INTEAVASCULAR HEMOLYSIS BY HAP-TOGLOBIN ADMINISTRATION AFTER PROSTHETIC VALVE REPLACEMENT
抄録
Although the measurement of serum haptoglobin (S-Hp) is of great use for evaluation of intravascular hemolysis, it is not applicable in patients with mechanical prosthetic valves because S-Hp is virtually absent. We administered haptoglobin preparation to ten patients with Bjork-Shiley mitral prosthetic valves and ten patients with the same aortic prosthetic valves. Serum haptoglobin levels were measured periodically afterwards. The maximum haptoglobin level (Hp(max)), serum haptoglobin reducing rate ((Hp-δHp)/δt) and expected haptoglobin disappearing time (hr) were obtained from the subsequent samples. The screening studies which were performed at the same time, such as red blood cell, hemoglobin, reticulocyte count, serum lactic dehydrogenase (LDH), ratio of LDH (1) /LDH (2), serum ferritin, serum indirect bilirubin, serum iron and hemoglobin levels were not predictors of difference of the two groups. On the other hand, serum haptoglobin reducing rate and expected haptoglobin disappearing time in-dicated that hemolysis is higher in patients with aortic prosthetic valve than with mitral prosthetic valve. This haptoglobin administration test seems to be useful for evaluation of subclinical intravascular hemolysis.
収録刊行物
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- 人工臓器
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人工臓器 21 (2), 649-652, 1992
一般社団法人 日本人工臓器学会
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詳細情報 詳細情報について
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- CRID
- 1390001204955310720
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- NII論文ID
- 130002389784
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- ISSN
- 18836097
- 03000818
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可