ハプトグロビン投与による弁置換術後慢性溶血の評価

DOI

書誌事項

タイトル別名
  • EVALUATION OF INTEAVASCULAR HEMOLYSIS BY HAP-TOGLOBIN ADMINISTRATION AFTER PROSTHETIC VALVE REPLACEMENT

抄録

Although the measurement of serum haptoglobin (S-Hp) is of great use for evaluation of intravascular hemolysis, it is not applicable in patients with mechanical prosthetic valves because S-Hp is virtually absent. We administered haptoglobin preparation to ten patients with Bjork-Shiley mitral prosthetic valves and ten patients with the same aortic prosthetic valves. Serum haptoglobin levels were measured periodically afterwards. The maximum haptoglobin level (Hp(max)), serum haptoglobin reducing rate ((Hp-δHp)/δt) and expected haptoglobin disappearing time (hr) were obtained from the subsequent samples. The screening studies which were performed at the same time, such as red blood cell, hemoglobin, reticulocyte count, serum lactic dehydrogenase (LDH), ratio of LDH (1) /LDH (2), serum ferritin, serum indirect bilirubin, serum iron and hemoglobin levels were not predictors of difference of the two groups. On the other hand, serum haptoglobin reducing rate and expected haptoglobin disappearing time in-dicated that hemolysis is higher in patients with aortic prosthetic valve than with mitral prosthetic valve. This haptoglobin administration test seems to be useful for evaluation of subclinical intravascular hemolysis.

収録刊行物

  • 人工臓器

    人工臓器 21 (2), 649-652, 1992

    一般社団法人 日本人工臓器学会

詳細情報 詳細情報について

  • CRID
    1390001204955310720
  • NII論文ID
    130002389784
  • DOI
    10.11392/jsao1972.21.649
  • ISSN
    18836097
    03000818
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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