ヘパリン徐放性癒着防止心膜の開発

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タイトル別名
  • Antiadhesive pericardium with heparin slow release.

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説明

Pericardial adhesions increased the morbidity of reoperative cardiac surgical procedures. Attempts to reduce these adhesions have had limited success. Antiadhesive pericardium with heparin slow release was newly developed. The membrane was cross-linked by glutaraldehyde and heparinized ionically using protamine. Animal studies revealed that the membrane had excellent antiadhesive property. No or little adhesions were observed between the heart and the pericardial patches in 6 out of 7 dogs. It didn't cause a fibrotic reaction at the epicardial surface. Glutaraldehyde-fixed ethanol-preserved porcine pericardium with heparin slow release is a safe, effective pericardial substitute and must serve to prevent most postoperative cardiac adhesions.

収録刊行物

  • 人工臓器

    人工臓器 17 (2), 566-569, 1988

    一般社団法人 日本人工臓器学会

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