In vivo effects of modified hemoglobin as an artificial oxygen carrier.

DOI

Bibliographic Information

Other Title
  • 人工的酸素運搬体としての修飾ヘモグロビンの生体内効果

Abstract

The pyridoxylated hemoglobin (PLP-Hb) was conjugated with polyethylene glycol (PEG) and tested for its biological half life (T1/2) and safety by exchange-transfusion in rats. The T1/2 of the PLP-Hbs conjugated with PEG 4, 000, 5, 000 or 6, 000 molecular weight was significantly increased as compared with that of stroma-free hemoglobin and PLP-Hb. However, there was no remarkable change in T1/2 and P50 value among them. Some of the hemoglobin preparations caused the elevation of GOT, GPT or cholesterol level in plasma one day after exchange-transfusion or the decline of alkaline phosphatase for 7 days. All of the test values were back to normal range after 14 days. The results suggest that the hemoglobin preparations do not cause serious side effects in vivo. However, it is indispensable to investigate the toxicity and infectivity of the contaminants in hemoglobin preparations before their application to human as artificial oxygen carrier.

Journal

  • Jinko Zoki

    Jinko Zoki 17 (6), 1690-1695, 1988

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

Keywords

Details 詳細情報について

  • CRID
    1390001204958249856
  • NII Article ID
    130001734315
  • DOI
    10.11392/jsao1972.17.1690
  • ISSN
    18836097
    03000818
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top