Anti-tissue Antibodies in Sera and Urines of Patients with Nephritis

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  • Kasukawa Reiji
    II. Department of Medicine Fukushima Medical School and Department of Bacteriology & Immunology State University of New York at Buffalo
  • Sakamoto Tsugio
    II. Department of Medicine Fukushima Medical School and Department of Bacteriology & Immunology State University of New York at Buffalo
  • Milgrom Felix
    II. Department of Medicine Fukushima Medical School and Department of Bacteriology & Immunology State University of New York at Buffalo

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Other Title
  • 腎炎患者にみられた血中および尿中の抗組織抗体
  • ジンエン カンジャ ニ ミラレタ ケッチュウ オヨビ ニョウ チュウ ノ コウソシキ コウタイ

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Abstract

Two patients with chronic glomerulonephritis contained antibodies which combined with antigens of normal kidney and other organs. These antigens could be detected in tissue extracts prepared by prolonged autolysis, urea or sodium deoxycholate treatment but not in plain saline extracts of the tissues. Related antigens were detected in 6 of 70 sera originated from patients with various renal disorders. Of these 6 patients, four excreted the antigens into urines. One of the above mentioned two patients with glomerulonephritis and the other with lupoid nephritis whose serum contained antibodies to cytoplasmic antigens excreted the antibodies into urines.

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