Studies on Antibody Producing Capacity of the Patients with Allergic Diseases and Collagen Diseases

DOI Web Site
  • Takeda Koyo
    Department of Physical Therapy and Medicine, School of Medicine, University of Tokyo

Bibliographic Information

Other Title
  • アレルギー性疾患および膠原病患者の抗体産生能に関する研究 : 主として気管支喘息患者および慢性関節リウマチ患者について
  • アレルギー性疾患および膠原病患者の抗体産生能に関する研究
  • アレルギーセイ シッカン オヨビ コウゲンビョウ カンジャ ノ コウタイ サンセイノウ ニ カンスル ケンキュウ

Search this article

Abstract

Antibody producing potency of patients with bronchial asthma, rheumatoid arthritis or other collagen diseases were investigated concerning ABO blood group isoagglutinis and skin sensitizing antibodies. The isoagglutinin levels of these patients were, as a whole, almost equivalent to those of controls. There was also no significant difference among these groups in elevation of the isoagglutinin titers after stimulation by subcutaneous injection of mismatched blood. A relatively weak response to the stimulation was observed in the patients with collagen diseases including 2 patients with S.L.E.. Positive skin reactions to house dust and ragweed extracts, were more frequently observed in the asthmatic group and, on the contrary, less frequently in the rheumatoid group than in the control group. But there was no such marked difference among them in skin reaction with monilia extract. Fifty-two subjects consisting of asthmatic, rheumatoid, and control patients received weekly intramuscular injections of ACTH-Zn preparation. Using aquous solution of an ACTH preparation at the concentration of 0.002 units/ml., it was proved that atopic asthmatic patients earlier and more frequently, and rheumatoid patients less frequently developed positive turn of the immediate skin reaction than the control group. The intensity of skin reactions to histamine and acetylcholine proved almost similar in three these groups, except that the threshold of skin reaction to acetylcholine was lower in rheumatoid patients.

Journal

Details 詳細情報について

Report a problem

Back to top