Effect of Anti-histamine and other Anti-inflammatory Drugs to Heterologous PCA Reaction in Rats and Mice

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  • ラット及びマウスの Heterologous PCA に及ぼす抗ヒスタミン剤並びに2・3の抗炎症剤の影響
  • ラット オヨビ マウス ノ Heterologous PCA ニ オヨボス コウヒスタミンザイ ナラビニ 2 , 3 ノ コウエンショウザイ ノ エイキョウ

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Abstract

The anti-allergic action of antihistaminics, quinoline- and pyrazolone-derivtives, was examined against the heterologous PCA elicited by rabbit anti-BSA sera in the rat and the mouse. The inhibitory action of these agents was also tested against the nonallergic increase in vascular permeability principally caused by histamine. The results were compared to those previously reported in the guineapig. 1) As in the guinea pig, antihistaminics such as diphenhydramine and promethazine had little effect on the PCA in the rat, except when a high dose of promethazine(25 mg/kg) was used. Diphenhydramine and triploridine were also almost insensitive to PCA in the mouse. 2) Of the quinoline-derivatives quinine inhibited the increased vascular permeability, both allergic (PCA) and non-allergic to nearly the same extent, which was similar to the results found in the guinea pig. This was also true of the mouse. Chloroquine, however, was more toxic in the rat than in the guinea pig. Therefore, it was impossible to demonstrate the anti-allergic action. 3) As in the guinea pig, pyrazolone-derivatives such as phenylbutazone and aminopyrin inhibited the PCA more strongly than histamine in the rat. In the mouse, however, only slight inhibition, if any, was produced against both PCA and histamine. From these results, it seems difficult to detect differences between the guinea pig and the rat with regard to the susceptibility of PCA to these reagents. Some difference, on the other hand, was observed between the rat and the mouse, though these two species were expected to be closely related.

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