Studies on the Vital Reactions by Anaphylaxis in the Liver : I. Changes in the Reversed Anaphylaxis by the Anti-red Cell Serum

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  • 肝に於けるアナフィラキシーによる生体反応に関する研究 : 第1報 抗赤血球血清による逆アナフィラキシー時の変化について
  • 肝におけるアナフィラキシーによる生体反応に関する研究-1-
  • キモ ニ オケル アナフィラキシー ニ ヨル セイタイ ハンノウ ニ カンスル ケンキュウ 1

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Based upon the Hamamoto's theory of "Intravascular Antigen-Antibody reaction", anti-rabbit red cell guinea pig serum were injected intravenously through the hepatic artery and portal vein of rabbits. Both histological changes in the liver and changes in various liver function tests caused by this reversed anaphylaxis were simultaneously investigated. The results obtained were as follows: 1) The most severe histological changes in the liver were observed in the rabbits injected provocatively into the hepatic artery and portal vein. Major changes in these groups were as follows: a) parenchymal necrotic foci, b) various degree of degeneration of liver cells, c) serous inflammation, d) thrombosis, e) fibrinoid swelling of arterial walls. No significant changes were found in the control animals. 2) Then, the electrophoretic pattern of serum protein fractions were as follows: a) decrease of total serum protein, b) declination of albumin, c) increase of α-and β-globulin, d) declination of gamma globulin. 3) The results of the liver function tests were slight positive only by the Cephalin-cholesterol flocculation test and Cobalt reaction. The significant correlation between these patho-histological changes and the grade of functional disturbances of the liver were discussed.

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