Measurement of Specific IgG Antibody Using Protein A-Sepharose CL-4B in Patients Treated with Hyposensitization Therapy

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  • 気管支喘息減感作例における Protein A-Sepharose CL-4B による特異的 IgG 抗体の測定
  • キカンシ ゼンソクゲンカン サクレイ ニ オケル Protein A Seph

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Abstract

Anti-hoya (sea-squirt) IgG antibody was measured by radioimmunoassay using Protein A-Sepharose CL-4B. In comparison with healthy adults (group A), anti-hoya IgG value of healthy oyster workers (group B), not hyposensitized hoya-asthma cases (group C) and hyposensitized hoya-asthma cases (group D) was significantly higher. Anti-hoya IgG value of group D was significantly higher than that of group B and group C, but there was no difference between group B and group C. When hyposensitization was conducted ones a week, anti-hoya IgG value of group D made a rapid increase immediately after the treatment was commenced and after 4-5 months the value reached a peak, followed thereafter by an almost constant level. The value did not decrease even during the off-season so long as maintenance therapy was provided. When the interval of hyposensitization injection was a month, anti-hoya IgG value showed still moderately high level but when the interval was extended to 2-3 months or more, the value did not showed much difference from the group C. Anti-hoya IgE and IgG value was measured using the same serum. In group A, both the anti-hoya IgE and IgG value was low. In group B, anti-hoya IgE value was low as in cases of group A and anti-hoya IgG value was higher than that of group A. In group C, anti-hoya IgE value was markedly high as in cases of group D and anti-hoya IgG value was as high as that of group B. In group D, anti-hoya IgG value was higher than that of any other groups.

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