Studies on the Change of Histamine Levels in the Blood of Infants and Children : Part 4.Effect of H_1 Blocker, Chlorpheniramine, and Prostaglandin E_1 on Histamine Sensitive Adenyl Cyclase, Blood Histamine Levels and Respiratory Functions of Asthmatic Children

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  • 小児血中ヒスタミンの変動に関する研究 : 第4報 喘息児の呼吸機能の改善と血中ヒスタミンおよび cAMP の変動におよぼす H_1 Blocker および PGE_1 投与の影響について
  • 小児血中ヒスタミンの変動に関する研究-4-喘息児の呼吸機能の改善と血中ヒスタミンおよびcAMPの変動におよぼすH, BlockerおよびPGE,投与の影響について
  • ショウニ ケッチュウ ヒスタミン ノ ヘンドウ ニカンスルケンキュウ 4 ゼン

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Abstract

The Purpose of this study was to approve the hypothesis that chlorpheniramine (c.p.), an H_1 blocker, can cause bronchodilation if administered orally in less doses than those currently prescribed in accordance with the effect of cyclase activation by PGE_1. In 9 subjects with asthma, FVC, FEV_1, FEF_<25-75%> and RR were recored on different days before and up to 2 hr after administration of 6 to 10 mg per os chlorpheniramine with or without 10 and 20 μg PGE_1 inhalation. PGE_1 was inhaled from a pressure cycled ventilator (Bennet) in the time of 90 min after c.p. administration. c.p. with PGE_1 produced reproducible increases in FEF_<25-75%> and also resulted in an increase of plasma cAMP with a decrease of blood histamine levels and RR. The increase averaged 33.5% for FEF_<25-75%> and the average decrease in RR was 40%. Mean blood histamine levels before and 2 hr later after c.p. administration with or without PGE_1 were 0.04±0.01, 0.066±0.015 and 0.048±0.011, 0.087±0.009 (μg/ml), respectively. Mean plasma cAMP levels were 7.4±2.1, 5.9±2.8 and 6.4±5.1, 8.8±1.0 (p mol/ml) with 10 and 20μg PGE_1 inhalation in addition of c.p. administration. These results suggest that there are at least two types of receptors by this in vivo-studies, i.e. one is responsive to histamine and the other to the prostaglandin.

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