Histamine and Hypersensitivity Reaction of Immediate Type in Human Lung

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  • Suzuki Shuji
    Department of Physical Therapy and Internal M dicine, University of Tokyo

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  • ヒト肺における即時型アレルギー反応とヒスタミン
  • ヒト ハイ ニ オケル ソクジガタ アレルギー ハンノウ ト ヒスタミン

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Abstract

It is impossible now to affirm that the hypersensitivity reaction of immediate plays a definite role in every case with bronchial asthma. However, some of the patients with this disorder reveal positive skin tests or inhalation tests by specific antigens and their sera sometimes yield positive PK reactions. Before concluding whether or not a certain substance mediates the hypersensitivity reaction of immediate type in a certain organ, it is essential to check the following: 1) Is the substance or its precursor containced in the organ? 2) Is the substance released from the sensitized organ when challenged with specific antigens? 3) Is the substance able to elicit the symptoms skin to those evoked by the hypersensitivity reaction of immediate type in the organ? 4) Is the substance metabolized in the organ? This review on the relationship between histamine and the hypersensitivity reaction of immediate type in the human lung makes the following clear: 1) Histamine is contained in the human lung. 2) Histamine is released from the sensitized human lung when challenged with specific antigens. 3) It has not been certain whether the effect of histamine and that of antigens on the sensitized human lung are similar or different. 4) Mysteries on the metabolism of histamine in the human lung have scarecely uncovered.

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