CHARACTERIZATION OF LYMPHOCYTIC CELLS INFILTRATING INTO THE FOLLICULAR EPITHELIAL LINING IN CHRONIC THYROIDITIS IN HUMANS

DOI Web Site

Bibliographic Information

Other Title
  • ヒト慢性甲状腺炎における甲状腺濾胞上皮細胞列侵入細胞の検討
  • ヒト マンセイ コウジョウセンエン ニ オケル コウジョウセン ロホウ ジョウ

Search this article

Abstract

Lymphocytic cells infiltrating into the follicular epithelial lining were studied with immunofluorescence and electron microscopy to understand a mechanism destructive of thyroid tissue in chronic thyroiditis in humans. Medium to large T cells infiltrated first, followed by plasma cells with progress of thyroid lesion. T cells infiltrating into the follicular epithelial lining consisted of two types of cells, medium to large T cells with rich cytoplasm and small T cells with poor cytoplasm. The former were found more frequently than the latter and were observed at a very early stage in chronic thyroiditis. Furthermore, it was found that degeneration of follicular epithelium had already begun when the former cells infiltrated into the follicular epithelial lining. Medium to large T cells had been thought to be important in the destruction of follicular epithelial cells. According to our study, T cells seem to play a causal role in the destruction of follicular epithelial cells.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top