Studies on Immunosuppressive Active Substance in Human Serum : I. Influence of Sera from Healthy Individuals and Patients with a Variety of Respiratory Diseases on Plaque-Forming Cell Response to Sleep Red Blood Cell in Mice

Suginouchi Toshihiko

doi:10.15036/arerugi.27.756

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ヒト血清中の免疫抑制作用物質に関する研究 : 第1編健常人および各種呼吸器疾患患者血清のマウスにおけるヒツジ赤血球に対する抗体産生におよぼす影響
ヒト血清中の免疫抑制作用物質に関する研究-1-健康人および各種呼吸器疾患患者血清のマウスにおけるヒツジ赤血球に対する抗体産生におよぼす影響
ヒトケッセイチュウノメンエキヨクセイサヨウブッシツニカンスルケン

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Attempts were made to demonstrate whether there was a serum suppressive effect in patients with a variety of respiratory diseases or not, using as a index the inhibition of induction of the plaqueforming cell in the spleen od mice immunized with sheep red blood cells. Studies were also made to determine if there were any associations between the suppressive effect and clinical findings of these same cares studied through this paper. 1. Serum suppressive effect was detected in 4 of 9 healthy individuals over 70 years old, but there was no evidence of this effect in 35 healthy individuals ranging in age 10 to 69 years old. 2. Serum suppressive effect was demonstrated in 19 of 19 patiens with pulmonary cancer;in 13 of 13 patients with active pulmonary tuberculosis and in 2 of 8 cured patients;in 18 of 20 patients with active sarcoidosis and in 4 of 6 cured patients;in 5 of 5 patients with chronic berylliosis;but not in any of 3 patients with bronchoectasis and 3 patients with bronchitis. 3. The frequency of case showing the serum suppressive effect appeared significantly higher in active pulmonary tuberculosis, when compared to those cured, but not in pulmonary cancer and sarcoidsis. 4. It was shown that the serum suppressive effect was not based on heterophile antibody to sheep red blood cell.

Journal

Japanese Journal of Allergology

Japanese Journal of Allergology 27 (9), 756-765,768-76, 1978

Japanese Society of Allergology

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