EFFECT OF IMMUNOPOTENTIATING AGENTS (BCG, PICIBANIL, LEVAMISOLE) AND MARUYAMA VACCINE ON NEUTROPHIL FUNCTIONS INCLUDING THE GENERATION OF OXYGEN INTERMEDIATES

DOI Web Site

Bibliographic Information

Other Title
  • 免疫増強剤(BCG, Picibanil, Levamisole)および丸山ワクチンの活性酸素産生能を中心とした好中球機能におよぼす影響について
  • メンエキ ゾウキョウザイ BCG Picibanil Levamisole オ

Search this article

Description

The immunopotentiating agents including BCG, picibanil and levamisole have been widely used for the treatment of malignant tumor and autoimmune diseases. The possible action mechanisms of these drugs have often been investigated in connection with lymphocytes. Maruyama vaccine is, though its mechanism is unknown, also used for therapy of malignancies by many clinicians. Recently, it has been shown that oxygen intermediates (OI) display strong antibactericidal function and play an important role in the body's defense system. Furthermore, a chemotherapeutic agent, Bleomyan has been reported to be effective in the treatment of cancer by increasing the generation of hydroxyl radical, one of the most potent OI, with subsequent destruction of DNA in cancer cells. On the other hand, it had been verified that an excessive increase in OI generation plays some role in impairments of lymphocytes and disturbed immunoreactivity in patients with SLE and in synovial fluid of RA patients. These facts prompted us to investigate the dose-dependent effect of these four drugs on the neutrophil functions including phagocytosis of human neutrophils and the capacity to release lysosomal enzymes (β-glucuronidase and lysozyme) and to generate OI (O^-_2, H_2O_2, OH・) and chemiluminescence. The following results were obtained: BCG in all the concentrations used and Maruyama vaccine at the lower concentrations induced a marked increase in OI generation by human neutrophils in a dose responsive manner, while a remarkable decrease in OI production was noted in the presence of levamisole in all the concentrations and of Maruyama vaccine at the higher concentrations. Our present study indicates that, from the standpoint of OI generation by phagocytes, effect of immunopotentiating agents (BCG, picibanil, levamisole) and Maruyama vaccine on PMNL may be recommended by both sides on decreased and increased OI production.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top