URINARY LEUKOTRIENES LEVELS IN ASTHMATIC CHILDREN

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  • 喘息患児の病態と尿中ロイコトリエンB_4, C_4濃度との関係

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Abstract

In order to investigate the possible contribution of leukotrienes to the airway hypersensitivenes and inducibility of asthmatic spells, the probable temporal correlation of the urinary leukotriene levels (U-LTB_4 and U-LTC_4) were estimated along with the peripheral neutrophil counts in two groups of asthmatic children with or without an inflammatory sign of the elevated CRP. The first group consisted of 6 asthmatic children possessing inflammatory signs and symptoms of fever and peripheral leukocytosis. They all were hospitalized. The second group of 6 patients of light asthmatic attack without any signs and symptoms of acute inflammation were studied in the Outpatient Department. In the first group, U-LTB_4 was as high as 258.6±88.9ng/mmol Cr. during the attacks while U-LTB_4 levels of the second group was as low as 62.2±32.20 ng/mmol Cr. The difference was statistically significant at p<0.01. Further mathematical analysis revealed a positive correlation of U-LTB_4 to the peripheral neutrophils counts at r=0.71. Thus, it was concluded that the elevation of U-LTB_4 levels in the first group was strongly related to infections, and their asthmatic spells were thought to represent an infection-induced type. On the contrary, U-LTC_4 levels in the samples during the athmatic attacks were increased in 2 of the 6 of the first group. They both represented grave asthmatic spells. In the remainder, U-LTC_4 levels did not rise enough to induce spasmodic contractions of the bronchial smooth muscles. Thus, it was also discussed that the most appropriate timing for urine collection for the study of U-LTs is some time following an asthmatic attack.

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