USEFULNESS OF INHALED STEROIDS IN STEROID-DEPENDENT INTRACTABLE ASTHMA : Equivalent Dose of Oral Steroid to Inhaled Steroid

DOI 3 Citations
  • Takahashi Kiyoshi
    Department of Internal Medicine, National Sanatorium Minami Okayama Hospital
  • Kotoh Naoki
    Department of Second Internal Medicine, Okayama University Medical School
  • Soda Ryo
    Department of Internal Medicine, National Sanatorium Minami Okayama Hospital
  • Tada Shinya
    Department of Second Internal Medicine, Okayama University Medical School
  • Tanizaki Yoshiro
    Department of Internal Medicine, Division of Medicine, Misasa Branch Hospital Okayama University Medical School
  • Kimura Ikuro
    Department of Second Internal Medicine, Okayama University Medical School

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Other Title
  • ステロイド依存性難治性喘息患者における吸入 ステロイド薬の有用性に関する検討 : 経口ステロイド薬との換算用量を中心に

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Twenty-four steroid-dependent intractable asthmatics were treated with oral prednisolone (PSL) (basic dose) + additional PSL and oral PSL (basic dose) + inhaled beclomethasone (BDP) alternately, to assess the clinical symptoms in each administration period. Equivalent doses of PSL to BDP were calculated. 1. Peak expiratory flow rate (PEF) during additional administration of BDP was markedly higher both in the morning and at night compared with that during additional administration of PSL (p<0.01 and p<0.05 respectively). 2. The relation between additional doses of either PSL or BDP and attack scores was analysed in regression to obtain a dose equivalence line. 3. BDP 400 μg was equivalent to PSL 7.04 mg on average. 4. The equivalent dose of PSL to BDP tended to be lower in cases where the priod of dependency on oral steroids was longer, the basic dose was larger, or the asthma was more severe. These data indicate that the application of inhaled steroids may be useful in the therapeutic management of steroid-dependent intractable asthmatics.

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