TRIAL OF ISOLATION OF SICK HOUSE SYNDROME AND UNCLASSIFIED MULTIPLE CHEMICAL SENSITIVITIES : Definition of Sick House Syndrome, and Symptoms

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  • Torii Sinpei
    Department of Home Economics, Aichi Gakusen University
  • Hirayama Khoichiro
    Clinical Data Care Japan Co., Ltd.
  • Akiyama Kazuo
    Clinical Research Center, National Hospital Organization, Sagamihara National Hospital
  • Ikezawa Zenro
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine
  • Uchio Eiichi
    Department of Ophthalmology Fukuoka University School of Medicine
  • Okamoto Yoshitaka
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University
  • Ogura Hideo
    Department of Pediatrics, National Hospital Organization, Kochi National Hospital
  • Takahashi Kiyoshi
    Department of Internal Medicine, National Hospital Organization, Minami-Okayama Medical Center
  • Nishima Sankei
    Clinical Research Center, National Hospital Organization, Fukuoka National Hospital

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Other Title
  • シックハウス症候群と未分類の多種化学物質過敏症の分離の試み : シックハウス症候群の定義および症状
  • シックハウス ショウコウグン ト ミブンルイ ノ タシュ カガク ブッシツ カビンショウ ノ ブンリ ノ ココロミ シックハウス ショウコウグン ノ テイギ オヨビ ショウジョウ

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Abstract

Purpose: This study was designed to clarify the definition of sick house syndrome (SHS). Methods: SHS was defined based on the disease related to habitation as follows. 1. The cause of the onset of a disease relates to house. 2. Symptoms appear within house. 3. Symptoms will be less serious or disappear if patient away from house. 4. If patient goes into house, symptoms will appear repeatedly. When it corresponded to all above, it was defined to SHS, and it classified as MCS (multiple chemical sensitivities) without above conditions. Even if SHS is isolated from similar disease completely, characteristic symptoms of MCS are hard to be detected because MCS are combination of two or more diseases. Based on this working hypothesis, the logistic regression by setting MCS as reference was performed so that characteristic symptoms of SHS show odds ratios with exceeding one. Results: The odds ratios with more than two of characteristic symptoms in SHS were "nausea or vomiting" "Troublesome in everything" and the causative substances to which symptoms get worse was "The smell of a perfume and cosmetics". Characteristic symptoms of an allergy disease were detected by comparison with the allergic conjunctivitis, allergic rhinitis, and bronchial asthma, respectively. Conclusion: These results showed that the classification method was appropriate. This definition is not fundamentally differed from the definition of the sick-building syndrome of WHO.

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