FEATURE OF FOOD ALLERGY DEVELOPED DURING INFANCY (1) : Relationship Between Infantile Atopic Dermatitis and Food Allergy

DOI Web Site 10 Citations 35 References
  • Ikematsu Kaori
    Department of Pediatrics, Tokyo Jikei University School of Medicine:Clinical Research Center For Allergy and Rheumatology, Department of Allergy, National Hospital Organization, Sagamihara National Hospital
  • Tachimoto Hiroshi
    Division of Pediatric Allergy, National Hospital Organization, Sagamihara National Hospital:Clinical Research Center For Allergy and Rheumatology, Department of Allergy, National Hospital Organization, Sagamihara National Hospital
  • Sugisaki Chizuko
    Clinical Research Center For Allergy and Rheumatology, Department of Allergy, National Hospital Organization, Sagamihara National Hospital
  • Syukuya Akinori
    Division of Pediatric Allergy, National Hospital Organization, Sagamihara National Hospital
  • Ebisawa Motohiro
    Clinical Research Center For Allergy and Rheumatology, Department of Allergy, National Hospital Organization, Sagamihara National Hospital

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Other Title
  • 乳児期発症食物アレルギーに関する検討(第1報) : 乳児アトピー性皮膚炎と食物アレルギーの関係
  • ニュウジキ ハッショウ ショクモツ アレルギー ニ カンスル ケントウ ダイ1ポウ ニュウジ アトピーセイ ヒフエン ト ショクモツ アレルギー ノ カンケイ

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Abstract

Background: Most of food allergy (FA) cases during childhood start as infantile atopic dermatitis (AD) at the ages of a few months old. We tried to clarify the association between infantile AD and FA during infancy. Methods: We analyzed relationship between AD and FA during infancy among patients with 208 cases, who had visited our outpatient clinic with chief complaint of "eczema" from 1998 to 2000. Results: Among 208 cases, 148 cases (71%) were diagnosed as infantile AD, moreover 109 cases (74%) were diagnosed as FA among infantile AD. The most frequent food antigens among infantile AD were egg (72.3%), cow's milk (39.9%), wheat (12.2%) and soybean (7.4%), respectively, in addition to these food antigens, food allergy was widely recognized against peanuts, sesame, meats, buckwheat, fishes and potato. In terms of food antigen, 44 cases with single food allergy against egg were seen out of 46 single allergy cases, whereas 36 cases with double food allergy against both egg and cow's milk were seen in 63 multiple food allergy cases. Although the value of antigen specific IgE against egg and cow's milk was recognized for the diagnosis of food allergy during infancy, even cases with negative IgE against those foods were proved to be food allergy by food elimination and provocation tests. In contrast to egg and cow's milk, positive IgE against rice, soybean, and wheat did not always correlate with the results of the diagnosis of food allergy. Concerning risk factors of AD, family history of any allergy diseases and passive smoking were recognized in comparison with infantile eczema. Neither the nutrition method nor incomplete elimination of diet during pregnancy and lactation had anything to do with the development of AD. Conclusion: When infantile AD cases were not improved by environmental control, skin care and application of steroid ointment, it would be important for doctors to think of the possibility of FA.

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