A CASE OF PRIMARY SJOGREN'S SYNDROME WITH HYPEREOSINOPHILIA AND ELEVATION OF SERUM IgE : MEASUREMENTS OF SERUM IL-4, IL-5 AND THE IgG SUBCLASS

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  • Azuma Naoto
    Division of Allergy and Clinical Immunology, National Hospital Organization Osaka-Minami Medical Center
  • Katada Yoshinori
    Division of Allergy and Clinical Immunology, National Hospital Organization Osaka-Minami Medical Center
  • Harada Yoshinori
    Division of Allergy and Clinical Immunology, National Hospital Organization Osaka-Minami Medical Center
  • Arimoto Hiroe
    Division of Otorhinolaryngology, National Hospital Organization Osaka-Minami Medical Center
  • Kimura Yoshimi
    Division of Otorhinolaryngology, National Hospital Organization Osaka-Minami Medical Center
  • Terada Haruko
    Division of Internal medicine for Respiratory system, National Hospital Organization Osaka-Minami Medical Center
  • Tsujino Kazuyuki
    Division of Internal medicine for Respiratory system, National Hospital Organization Osaka-Minami Medical Center
  • Kida Hiroshi
    Division of Internal medicine for Respiratory system, National Hospital Organization Osaka-Minami Medical Center
  • Yamamoto Suguru
    Division of Internal medicine for Respiratory system, National Hospital Organization Osaka-Minami Medical Center
  • Kudo Eriko
    Division of Rheumatology, National Hospital Organization Osaka-Minami Medical Center
  • Umeshita Mitsuko
    Division of Rheumatology, National Hospital Organization Osaka-Minami Medical Center
  • Mima Toru
    Division of Rheumatology, National Hospital Organization Osaka-Minami Medical Center
  • Saeki Yukihiko
    Department of Clinical investigation, National Hospital Organization Osaka-Minami Medical Center

Bibliographic Information

Other Title
  • 血清IL-4, IL-5およびIgG分画を測定した末梢血好酸球増加と血清IgE上昇を伴った原発性Sjogren症候群の1例
  • 症例報告 血清IL-4, IL-5およびIgG分画を測定した末梢血好酸球増加と血清IgE上昇を伴った原発性Sjogren症候群の1例
  • ショウレイ ホウコク ケッセイ IL 4 IL 5 オヨビ IgG ブンカク オ ソクテイ シタ マッショウケツ コウサンキュウ ゾウカ ト ケッセイ IgE ジョウショウ オ トモナッタ ゲンパツセイ Sjogren ショウコウグン ノ 1レイ

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A62-year-old man admitted to our hospital because of dry eyes and thirst. On admission, his bilateral parotid and submandibular glands were swelling. Laboratory data revealed severe eosinophilia (3309/μl), elevated serum IgE (1821IU/dl) and hypergammaglobulinemia (IgG 6049mg/dl). Interstitial pneumonia and renal dysfunction were present. He was diagnosed with Sjogren's syndrome (SjS) according to the European criteria. After the initiation of the therapy with 30mg of prednisolone, all abnormal findings including salivation ameliorated promptly. In the absence of any other obvious causes of eosinophilia and elevation of serum IgE, these findings might be associated with SjS itself. Moreover, both serum IL-5 and IgG4 levels were elevated in this patient, suggesting that Th2 type cytokines were dominant. Elevation of serum IgE and IgG4, and hypereosinophilia were likely to be reactive. To our knowledge, there have been no reports of these cytokines and of IgG subclass in such patients. We propose the existence of Th2-type-cytokine-dominant subtype of SjS.

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