CHOLINERGIC URTICARIA SUCCESSFULLY TREATED BY IMMUNOTHERAPY WITH PARTIALLY PURIFIED SWEAT ANTIGEN
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- Tanaka Toshihiko
- Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
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- Ishii Kaori
- Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
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- Suzuki Hidenori
- Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
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- Kameyoshi Yoshikazu
- Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
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- Hide Michihiro
- Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
Bibliographic Information
- Other Title
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- 汗の減感作療法が奏効したコリン性蕁麻疹の1例
- 症例報告 汗の減感作療法が奏効したコリン性蕁麻疹の1例
- ショウレイ ホウコク アセ ノ ゲン カンサ リョウホウ ガ ソウコウ シタ コリンセイ ジンマシン ノ 1レイ
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Abstract
A 24-years-old man was referred to our University Hospital because of one and a half-year history of disabling symptoms related to physical exertion. Multiple small round-shaped wheals with severe itch were induced by exercise, warmth and psychological stress. These symptoms were resistant to histamine Hi-receptor antagonists. Similar eruptions were induced by sauna-bathing, and skin test with autologous sweat showed a flare and wheal reaction. Incubation of his peripheral-blood leukocytes with partially purified sweat antigen evoked marked histamine release, indicating that he has been IgE-sensitized to an antigen(s) in human sweat. Specific immunotherapy using partially purified sweat antigen was performed every other week. Both pruritus and wheals improved gradually, and the reactivity of his peripheral blood leukocytes against sweat antigen decreased as immunotherapy was proceeded. Specific immunotherapy using sweat antigen may be valuable for patients with cholinergic urticaria with type I hypersensitivity to sweat antigen(s).
Journal
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- Japanese Journal of Allergology
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Japanese Journal of Allergology 56 (1), 54-57, 2007
Japanese Society of Allergology
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Details 詳細情報について
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- CRID
- 1390001204988747776
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- NII Article ID
- 110006164372
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- NII Book ID
- AN00012583
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- ISSN
- 13477935
- 00214884
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- NDL BIB ID
- 8671078
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed